Premier League giants Liverpool, Chelsea and Arsenal have been alerted over the availability of Real Madrid star Isco, according to reports.
The Spain international is understood to have made up his mind to exit the Bernabeu in the winter transfer window.
According to The Express, the former Malaga man has told Los Blancos president Florentino Perez that he is seeking a new challenge away from La Liga in the New Year.
Isco has struggled to attain sufficient game-time this season, following the arrival of Mateo Kovacic from Inter Milan over the summer.
Real Madrid currently rate the midfielder at around £35m.